5EIG
Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
Summary for 5EIG
Entry DOI | 10.2210/pdb5eig/pdb |
Descriptor | Cystathionine gamma-lyase, SULFATE ION, CYSTEINE, ... (5 entities in total) |
Functional Keywords | cyst(e)inase, lyase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P32929 P32929 |
Total number of polymer chains | 8 |
Total formula weight | 359406.76 |
Authors | |
Primary citation | Cramer, S.,Saha, A.,Tadi, S.,Tiziani, S.,Yan, W.,Triplett, K.,Lamb, C.,Alters, S.,Johnson, D.,Zhang, Y.,DiGiovanni, J.,Georgiou, G.,Stone, E. Systemic Depletion of Serum L-Cyst(e)ine with an Engineered Human Enzyme Mediates Potent Induction of ROS and Cancer Ablation To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
Download full validation report