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5EIC

Crystal structure of the bromodomain of human CREBBP in complex with AYC

Summary for 5EIC
Entry DOI10.2210/pdb5eic/pdb
DescriptorCREB-binding protein, 1,2-ETHANEDIOL, 2-[(chloroacetyl)amino]-5-[(E)-(4-sulfophenyl)diazenyl]benzenesulfonic acid, ... (4 entities in total)
Functional Keywordstransferase, transferase-inhibitor complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight29004.68
Authors
Dong, J.,Caflisch, A. (deposition date: 2015-10-29, release date: 2016-11-16, Last modification date: 2024-01-10)
Primary citationZhu, J.,Dong, J.,Batiste, L.,Unzue, A.,Dolbois, A.,Pascanu, V.,Sledz, P.,Nevado, C.,Caflisch, A.
Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9:929-934, 2018
Cited by
PubMed: 30258543
DOI: 10.1021/acsmedchemlett.8b00286
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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