5EIA

mACHE-anti TZ2PA5 complex from a 1:6 mixture of the syn/anti isomers

Summary for 5EIA

Entry DOI	10.2210/pdb5eia/pdb
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-phenyl-5-[5-[1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]-1,2,3-triazol-4-yl]pentyl]phenanthridin-5-ium-3,8-diamine, ... (5 entities in total)
Functional Keywords	acetylcholinesterase, inhibitor, click chemistry, triazole, hydrolase
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	121903.70
Authors	Bourne, Y.,Marchot, P. (deposition date: 2015-10-29, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Bourne, Y.,Sharpless, K.B.,Taylor, P.,Marchot, P. Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase. J.Am.Chem.Soc., 138:1611-1621, 2016 Cited by PubMed: 26731630 DOI: 10.1021/jacs.5b11384 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation