5EHP
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP836
Summary for 5EHP
Entry DOI | 10.2210/pdb5ehp/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | phosphatase ptp inhibitor ptpn11 allosteric, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 122134.36 |
Authors | |
Primary citation | Garcia Fortanet, J.,Chen, C.H.,Chen, Y.N.,Chen, Z.,Deng, Z.,Firestone, B.,Fekkes, P.,Fodor, M.,Fortin, P.D.,Fridrich, C.,Grunenfelder, D.,Ho, S.,Kang, Z.B.,Karki, R.,Kato, M.,Keen, N.,LaBonte, L.R.,Larrow, J.,Lenoir, F.,Liu, G.,Liu, S.,Lombardo, F.,Majumdar, D.,Meyer, M.J.,Palermo, M.,Perez, L.,Pu, M.,Ramsey, T.,Sellers, W.R.,Shultz, M.D.,Stams, T.,Towler, C.,Wang, P.,Williams, S.L.,Zhang, J.H.,LaMarche, M.J. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J.Med.Chem., 59:7773-7782, 2016 Cited by PubMed: 27347692DOI: 10.1021/acs.jmedchem.6b00680 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
Download full validation report