5EHE

Crystal structure of human carbonic anhydrase isozyme II with 3-(benzylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide

Summary for 5EHE

• Entry DOI: 10.2210/pdb5ehe/pdb
• Related: 4QTL
• Descriptor: Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (7 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 30236.51

Authors

Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2015-10-28, release date: 2016-11-09, Last modification date: 2024-01-10)

• Primary citation: Zubriene, A.,Smirnov, A.,Dudutiene, V.,Timm, D.D.,Matuliene, J.,Michailoviene, V.,Zaksauskas, A.,Manakova, E.,Grazulis, S.,Matulis, D.; Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases.; ChemMedChem, 12:161-176, 2017; PubMed: 28001003; DOI: 10.1002/cmdc.201600509

Experimental method

X-RAY DIFFRACTION (1.5 Å)