5EEL

Grb7 SH2 with bicyclic peptide inhibitor

Summary for 5EEL

• Entry DOI: 10.2210/pdb5eel/pdb
• Related: 5EEQ
• Descriptor: Growth factor receptor-bound protein 7, Bicyclic Peptide Inhibitor, MALONIC ACID, ... (6 entities in total)
• Functional Keywords: sh2, inhibitor, bicyclic, signaling protein-peptide complex, signaling protein/peptide
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 12
• Total formula weight: 89883.70

Authors

Watson, G.M.,Gunzburg, M.J.,Wilce, M.C.J.,Wilce, J.A. (deposition date: 2015-10-23, release date: 2016-06-15, Last modification date: 2018-12-26)

• Primary citation: Gunzburg, M.J.,Kulkarni, K.,Watson, G.M.,Ambaye, N.D.,Del Borgo, M.P.,Brandt, R.,Pero, S.C.,Perlmutter, P.,Wilce, M.C.,Wilce, J.A.; Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.; Sci Rep, 6:27060-27060, 2016; PubMed: 27257138; DOI: 10.1038/srep27060

Experimental method

X-RAY DIFFRACTION (2.47 Å)