5EEC
Crystal structure of KPC-2 beta-lactamase in complex with the S02030 boronic acid inhibitor
Summary for 5EEC
Entry DOI | 10.2210/pdb5eec/pdb |
Related | 5EE8 |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, 1-{(2R)-2-(dihydroxyboranyl)-2-[(thiophen-2-ylacetyl)amino]ethyl}-1H-1,2,3-triazole-4-carboxylic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transition state inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 58232.77 |
Authors | Nguyen, N.Q.,van den Akker, F. (deposition date: 2015-10-22, release date: 2016-02-03, Last modification date: 2016-03-09) |
Primary citation | Nguyen, N.Q.,Krishnan, N.P.,Rojas, L.J.,Prati, F.,Caselli, E.,Romagnoli, C.,Bonomo, R.A.,van den Akker, F. Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob.Agents Chemother., 60:1760-1766, 2016 Cited by PubMed: 26729491DOI: 10.1128/AAC.02643-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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