5EE7
Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893
Summary for 5EE7
Entry DOI | 10.2210/pdb5ee7/pdb |
Descriptor | Glucagon receptor,Endolysin,Glucagon receptor, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, OLEIC ACID, ... (6 entities in total) |
Functional Keywords | gpcr, signaling protein, 7tm |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P47871 |
Total number of polymer chains | 1 |
Total formula weight | 56370.97 |
Authors | Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Brown, A.J.H.,Cooke, R.M.,Weir, M.,Marshall, F.H. (deposition date: 2015-10-22, release date: 2016-04-20, Last modification date: 2024-01-10) |
Primary citation | Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Teobald, I.,Brown, A.J.,Cooke, R.M.,Weir, M.,Marshall, F.H. Extra-helical binding site of a glucagon receptor antagonist. Nature, 533:274-277, 2016 Cited by PubMed: 27111510DOI: 10.1038/nature17414 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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