5EE7

Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893

5EE7 の概要

• エントリーDOI: 10.2210/pdb5ee7/pdb
• 分子名称: Glucagon receptor,Endolysin,Glucagon receptor, 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid, OLEIC ACID, ... (6 entities in total)
• 機能のキーワード: gpcr, signaling protein, 7tm
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P47871
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56370.97

構造登録者

Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Brown, A.J.H.,Cooke, R.M.,Weir, M.,Marshall, F.H. (登録日: 2015-10-22, 公開日: 2016-04-20, 最終更新日: 2024-01-10)

• 主引用文献: Jazayeri, A.,Dore, A.S.,Lamb, D.,Krishnamurthy, H.,Southall, S.M.,Baig, A.H.,Bortolato, A.,Koglin, M.,Robertson, N.J.,Errey, J.C.,Andrews, S.P.,Teobald, I.,Brown, A.J.,Cooke, R.M.,Weir, M.,Marshall, F.H.; Extra-helical binding site of a glucagon receptor antagonist.; Nature, 533:274-277, 2016; PubMed: 27111510; DOI: 10.1038/nature17414

実験手法

X-RAY DIFFRACTION (2.5 Å)