5EDP

EGFR kinase (T790M/L858R) apo

Summary for 5EDP

• Entry DOI: 10.2210/pdb5edp/pdb
• Related: 5EDQ 5EDR
• Descriptor: Epidermal growth factor receptor (1 entity in total)
• Functional Keywords: protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 1
• Total formula weight: 37549.40

Authors

Eigenbrot, C.,Yu, C. (deposition date: 2015-10-21, release date: 2015-12-02, Last modification date: 2024-03-06)

• Primary citation: Hanan, E.J.,Baumgardner, M.,Bryan, M.C.,Chen, Y.,Eigenbrot, C.,Fan, P.,Gu, X.H.,La, H.,Malek, S.,Purkey, H.E.,Schaefer, G.,Schmidt, S.,Sideris, S.,Yen, I.,Yu, C.,Heffron, T.P.; 4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.; Bioorg.Med.Chem.Lett., 26:534-539, 2016; PubMed: 26639762; DOI: 10.1016/j.bmcl.2015.11.078

Experimental method

X-RAY DIFFRACTION (2.9 Å)