5EDE

human PDE10A in complex with 1-(4-Chloro-phenyl)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide at 2.2A

Summary for 5EDE

• Entry DOI: 10.2210/pdb5ede/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: Q9Y233 Q9Y233
• Total number of polymer chains: 4
• Total formula weight: 148319.28

Authors

Joseph, C.,Rudolph, M.G. (deposition date: 2015-10-21, release date: 2016-03-09)

• Primary citation: Kuhn, B.,Guba, W.,Hert, J.,Banner, D.,Bissantz, C.,Ceccarelli, S.,Haap, W.,Korner, M.,Kuglstatter, A.,Lerner, C.,Mattei, P.,Neidhart, W.,Pinard, E.,Rudolph, M.G.,Schulz-Gasch, T.,Woltering, T.,Stahl, M.; A Real-World Perspective on Molecular Design.; J.Med.Chem., 59:4087-4102, 2016; PubMed: 26878596; DOI: 10.1021/acs.jmedchem.5b01875

Experimental method

X-RAY DIFFRACTION (2.2 Å)