5ED2

Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene

Summary for 5ED2

• Entry DOI: 10.2210/pdb5ed2/pdb
• Related: 5ED1
• Descriptor: Double-stranded RNA-specific editase 1, RNA (5'-R(P*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3'), RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3'), ... (5 entities in total)
• Functional Keywords: deaminase, human, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 120961.47

Authors

Matthews, M.M.,Fisher, A.J. (deposition date: 2015-10-20, release date: 2016-04-13, Last modification date: 2023-09-27)

• Primary citation: Matthews, M.M.,Thomas, J.M.,Zheng, Y.,Tran, K.,Phelps, K.J.,Scott, A.I.,Havel, J.,Fisher, A.J.,Beal, P.A.; Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.; Nat.Struct.Mol.Biol., 23:426-433, 2016; PubMed: 27065196; DOI: 10.1038/nsmb.3203

Experimental method

X-RAY DIFFRACTION (2.95 Å)