5E8Z

TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH 3-AMINO-6-[4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE

Summary for 5E8Z

Entry DOI	10.2210/pdb5e8z/pdb
Related	5E8S 5E8T 5E8U 5E8V 5E8W 5E8X 5E8Y 5E90 5E91 5E92
Descriptor	TGF-beta receptor type-1, 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide (3 entities in total)
Functional Keywords	alk5, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P36897
Total number of polymer chains	1
Total formula weight	35585.94
Authors	Sheriff, S. (deposition date: 2015-10-14, release date: 2016-05-11, Last modification date: 2023-09-27)
Primary citation	Tebben, A.J.,Ruzanov, M.,Gao, M.,Xie, D.,Kiefer, S.E.,Yan, C.,Newitt, J.A.,Zhang, L.,Kim, K.,Lu, H.,Kopcho, L.M.,Sheriff, S. Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72:658-674, 2016 Cited by PubMed: 27139629 DOI: 10.1107/S2059798316003624 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.51 Å)

Structure validation