5E7V

Potent Vitamin D Receptor Agonist

Summary for 5E7V

DescriptorVitamin D3 receptor A, Nuclear receptor coactivator 1, 1-ALPHA-HYDROXY-27-NOR-25-O-CARBONYL-VITAMIN D3, ... (4 entities in total)
Functional Keywordstranscription, vitamin d nuclear receptor, vdr, ligand binding domain
Biological sourceDanio rerio (Zebrafish)
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Cellular locationNucleus Q9PTN2
Total number of polymer chains2
Total molecular weight36182.3
Authors
Otero, R.,Seoane, S.,Sigueiro, R.,Belorusova, A.Y.,Maestro, M.A.,Perez-Fernandez, R.,Rochel, N.,Mourino, A. (deposition date: 2015-10-13, release date: 2015-11-25, Last modification date: 2017-09-06)
Primary citation
Otero, R.,Seoane, S.,Sigueiro, R.,Belorusova, A.Y.,Maestro, M.A.,Perez-Fernandez, R.,Rochel, N.,Mourino, A.
Carborane-based design of a potent vitamin D receptor agonist.
Chem Sci, 7:1033-1037, 2016
PubMed: 28808527 (PDB entries with the same primary citation)
DOI: 10.1039/c5sc03084f
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.219205.9%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution