5E6T

Crystal structure of bovine norovirus P domain

Summary for 5E6T

• Entry DOI: 10.2210/pdb5e6t/pdb
• Descriptor: Capsid, ZINC ION (3 entities in total)
• Functional Keywords: viral protein, protruding domain
• Biological source: Norovirus Bo/GIII/B309/2003/BEL
• Total number of polymer chains: 2
• Total formula weight: 63237.56

Authors

Singh, B.K.,Hansman, G.S. (deposition date: 2015-10-10, release date: 2015-12-09, Last modification date: 2024-01-10)

Primary citation

Singh, B.K.,Koromyslova, A.,Hansman, G.S.
Structural analysis of bovine norovirus protruding domain.
Virology, 487:296-301, 2015

PubMed Abstract: We determined a structure of a bovine (genogroup III, GIII) norovirus capsid protruding (P) domain using X-ray crystallography. The bovine P domain was reminiscent of other norovirus genogroups (GI, GII, GIV, and GV), but closely matched the human GI P domain. We also identified a monoclonal antibody that was capable of binding the five different (GI-GV) P domains. Our data suggests that genetically diverse noroviruses still contain common epitopes.

PubMed: 26599362
DOI: 10.1016/j.virol.2015.10.022

Experimental method

X-RAY DIFFRACTION (2.27 Å)