5E40

3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis with D-tyrosine bound in the phenylalanine binding site

Summary for 5E40

• Entry DOI: 10.2210/pdb5e40/pdb
• Related: 2YPO 2YPP 2YPQ 3KGF 3NUD 3NUE 3NV8 3RZI 5E2L 5E4N
• Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, SULFATE ION, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: amino acid, allosteric regulation, shikimate pathway, 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase, transferase
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 102701.45

Authors

Reichau, S.,Jiao, W.,Parker, E.J. (deposition date: 2015-10-05, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Reichau, S.,Blackmore, N.J.,Jiao, W.,Parker, E.J.; Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.; Plos One, 11:e0152723-e0152723, 2016; PubMed: 27128682; DOI: 10.1371/journal.pone.0152723

Experimental method

X-RAY DIFFRACTION (2.05 Å)