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5E2S

Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor

Summary for 5E2S
Entry DOI10.2210/pdb5e2s/pdb
DescriptorCarbonic anhydrase 2, ZINC ION, 2'-(propan-2-yl)biphenyl-4-sulfonamide, ... (4 entities in total)
Functional Keywordslyase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm : P00918
Total number of polymer chains1
Total formula weight29411.56
Authors
Ferraroni, M.,Supuran, C.T. (deposition date: 2015-10-01, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citationCornelio, B.,Laronze-Cochard, M.,Ceruso, M.,Ferraroni, M.,Rance, G.A.,Carta, F.,Khlobystov, A.N.,Fontana, A.,Supuran, C.T.,Sapi, J.
4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.
J.Med.Chem., 59:721-732, 2016
Cited by
PubMed: 26741028
DOI: 10.1021/acs.jmedchem.5b01771
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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