5E2S
Crystal structure of human carbonic anhydrase II in complex with the 4-(2-iso-propylphenyl)benzenesulfonamide inhibitor
Summary for 5E2S
Entry DOI | 10.2210/pdb5e2s/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 2'-(propan-2-yl)biphenyl-4-sulfonamide, ... (4 entities in total) |
Functional Keywords | lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29411.56 |
Authors | Ferraroni, M.,Supuran, C.T. (deposition date: 2015-10-01, release date: 2016-01-20, Last modification date: 2024-01-10) |
Primary citation | Cornelio, B.,Laronze-Cochard, M.,Ceruso, M.,Ferraroni, M.,Rance, G.A.,Carta, F.,Khlobystov, A.N.,Fontana, A.,Supuran, C.T.,Sapi, J. 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. J.Med.Chem., 59:721-732, 2016 Cited by PubMed: 26741028DOI: 10.1021/acs.jmedchem.5b01771 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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