5E2R

The crystal structure of the human carbonic anhydrase II in complex with a 1,1'-biphenyl-4-sulfonamide inhibitor

Summary for 5E2R

Entry DOI	10.2210/pdb5e2r/pdb
Related	5CJF
Descriptor	Carbonic anhydrase 2, ZINC ION, 4'-(4-aminobenzoyl)biphenyl-4-sulfonamide, ... (5 entities in total)
Functional Keywords	1'-biphenyl-4-sulfonamide, lyase, complex, inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29987.22
Authors	Alterio, V.,De Simone, G. (deposition date: 2015-10-01, release date: 2015-11-04, Last modification date: 2024-01-10)
Primary citation	La Regina, G.,Coluccia, A.,Famiglini, V.,Pelliccia, S.,Monti, L.,Vullo, D.,Nuti, E.,Alterio, V.,De Simone, G.,Monti, S.M.,Pan, P.,Parkkila, S.,Supuran, C.T.,Rossello, A.,Silvestri, R. Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J.Med.Chem., 58:8564-8572, 2015 Cited by PubMed: 26497049 DOI: 10.1021/acs.jmedchem.5b01144 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation