5E2K

Crystal structure of human carbonic anhydrase II in complex with the 4-(3-aminophenyl)benzenesulfonamide inhibitor

Summary for 5E2K

Entry DOI	10.2210/pdb5e2k/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 3'-aminobiphenyl-4-sulfonamide, ... (5 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29586.75
Authors	Ferraroni, M.,Supuran, C.T. (deposition date: 2015-10-01, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Cornelio, B.,Laronze-Cochard, M.,Ceruso, M.,Ferraroni, M.,Rance, G.A.,Carta, F.,Khlobystov, A.N.,Fontana, A.,Supuran, C.T.,Sapi, J. 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies. J.Med.Chem., 59:721-732, 2016 Cited by PubMed: 26741028 DOI: 10.1021/acs.jmedchem.5b01771 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation