5DW2
X-ray crystal structure of human BRD4(BD1) in complex with RVX297 to 1.12 A resolution
Summary for 5DW2
Entry DOI | 10.2210/pdb5dw2/pdb |
Related | 5DW1 |
Descriptor | Bromodomain-containing protein 4, 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | bromodomain, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 16001.38 |
Authors | White, A.,Fontano, E.,Suto, R.K. (deposition date: 2015-09-22, release date: 2016-06-22, Last modification date: 2024-03-06) |
Primary citation | Kharenko, O.A.,Gesner, E.M.,Patel, R.G.,Norek, K.,White, A.,Fontano, E.,Suto, R.K.,Young, P.R.,McLure, K.G.,Hansen, H.C. RVX-297- a novel BD2 selective inhibitor of BET bromodomains. Biochem.Biophys.Res.Commun., 477:62-67, 2016 Cited by PubMed: 27282480DOI: 10.1016/j.bbrc.2016.06.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.12 Å) |
Structure validation
Download full validation report