5DW2
X-ray crystal structure of human BRD4(BD1) in complex with RVX297 to 1.12 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bromodomain-containing protein 4 | polymer | 129 | 15329.6 | 1 | UniProt (O60885) Pfam (PF00439) In PDB | Homo sapiens (Human) | Protein HUNK1 |
| 2 | A | 2-{3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,7-dimethoxyquinazolin-4(3H)-one | non-polymer | 423.5 | 1 | Chemie (5GD) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A: 44 - 170 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15329.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 671.8 | |
| All* | Total formula weight | 16001.4 |
