5DTQ
Crystal structure of Dot1L in complex with inhibitor CPD3 [(2,6-dichlorophenyl)(quinolin-6-yl)methanone]
Summary for 5DTQ
Entry DOI | 10.2210/pdb5dtq/pdb |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2,6-dichlorophenyl)(quinolin-6-yl)methanone (3 entities in total) |
Functional Keywords | inhibitor, complex, methyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q8TEK3 |
Total number of polymer chains | 2 |
Total formula weight | 77517.50 |
Authors | Scheufler, C.,Be, C.,Moebitz, H.,Stauffer, F. (deposition date: 2015-09-18, release date: 2016-06-15, Last modification date: 2024-01-10) |
Primary citation | Scheufler, C.,Mobitz, H.,Gaul, C.,Ragot, C.,Be, C.,Fernandez, C.,Beyer, K.S.,Tiedt, R.,Stauffer, F. Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket. Acs Med.Chem.Lett., 7:730-734, 2016 Cited by PubMed: 27563394DOI: 10.1021/acsmedchemlett.6b00168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
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