5DSG
Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium
Summary for 5DSG
Entry DOI | 10.2210/pdb5dsg/pdb |
Descriptor | Muscarinic acetylcholine receptor M4,Endolysin,Endolysin,Muscarinic acetylcholine receptor M4, (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, OLEIC ACID, ... (8 entities in total) |
Functional Keywords | membrane, gpcr, signaling, antagonist, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 100704.59 |
Authors | Thal, D.M.,Kobilka, B.K.,Sexton, P.M.,Christopoulos, A. (deposition date: 2015-09-17, release date: 2016-03-16, Last modification date: 2024-03-13) |
Primary citation | Thal, D.M.,Sun, B.,Feng, D.,Nawaratne, V.,Leach, K.,Felder, C.C.,Bures, M.G.,Evans, D.A.,Weis, W.I.,Bachhawat, P.,Kobilka, T.S.,Sexton, P.M.,Kobilka, B.K.,Christopoulos, A. Crystal structures of the M1 and M4 muscarinic acetylcholine receptors. Nature, 531:335-340, 2016 Cited by PubMed: 26958838DOI: 10.1038/nature17188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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