5DRB

Crystal structure of WNK1 in complex with WNK463

Summary for 5DRB

• Entry DOI: 10.2210/pdb5drb/pdb
• Descriptor: Serine/threonine-protein kinase WNK1, N-tert-butyl-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl}piperidin-4-yl)-1H-imidazole-5-carboxamide (3 entities in total)
• Functional Keywords: kinase, inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Cytoplasm : Q9JIH7
• Total number of polymer chains: 1
• Total formula weight: 34002.01

Authors

Kohls, D.,Xie, X. (deposition date: 2015-09-15, release date: 2016-09-07, Last modification date: 2024-03-06)

• Primary citation: Yamada, K.,Park, H.M.,Rigel, D.F.,DiPetrillo, K.,Whalen, E.J.,Anisowicz, A.,Beil, M.,Berstler, J.,Brocklehurst, C.E.,Burdick, D.A.,Caplan, S.L.,Capparelli, M.P.,Chen, G.,Chen, W.,Dale, B.,Deng, L.,Fu, F.,Hamamatsu, N.,Harasaki, K.,Herr, T.,Hoffmann, P.,Hu, Q.Y.,Huang, W.J.,Idamakanti, N.,Imase, H.,Iwaki, Y.,Jain, M.,Jeyaseelan, J.,Kato, M.,Kaushik, V.K.,Kohls, D.,Kunjathoor, V.,LaSala, D.,Lee, J.,Liu, J.,Luo, Y.,Ma, F.,Mo, R.,Mowbray, S.,Mogi, M.,Ossola, F.,Pandey, P.,Patel, S.J.,Raghavan, S.,Salem, B.,Shanado, Y.H.,Trakshel, G.M.,Turner, G.,Wakai, H.,Wang, C.,Weldon, S.,Wielicki, J.B.,Xie, X.,Xu, L.,Yagi, Y.I.,Yasoshima, K.,Yin, J.,Yowe, D.,Zhang, J.H.,Zheng, G.,Monovich, L.; Small-molecule WNK inhibition regulates cardiovascular and renal function.; Nat.Chem.Biol., 12:896-898, 2016; PubMed: 27595330; DOI: 10.1038/nchembio.2168

Experimental method

X-RAY DIFFRACTION (1.65 Å)