5DQL
Crystal Structure of 2-vinyl glyoxylate modified isocitrate lyase from Mycobacterium tuberculosis
Summary for 5DQL
| Entry DOI | 10.2210/pdb5dql/pdb |
| Descriptor | Isocitrate lyase 1, MAGNESIUM ION, 4-hydroxy-2-oxobutanoic acid, ... (4 entities in total) |
| Functional Keywords | lyase-lyase inhibitor complex, lyase/lyase inhibitor |
| Biological source | Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) |
| Total number of polymer chains | 4 |
| Total formula weight | 189131.44 |
| Authors | Huang, H.-L.,Meek, T.D. (deposition date: 2015-09-14, release date: 2016-09-14, Last modification date: 2023-09-27) |
| Primary citation | Pham, T.V.,Murkin, A.S.,Moynihan, M.M.,Harris, L.,Tyler, P.C.,Shetty, N.,Sacchettini, J.C.,Huang, H.L.,Meek, T.D. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A., 114:7617-7622, 2017 Cited by PubMed: 28679637DOI: 10.1073/pnas.1706134114 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.782 Å) |
Structure validation
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