5DP7

Crystal Structure of EV71 3C Proteinase in complex with compound 5

Summary for 5DP7

• Entry DOI: 10.2210/pdb5dp7/pdb
• Related: 5DP3 5DP4 5DP5 5DP6 5DP8 5DP9 5DPA
• Descriptor: 3C proteinase, ethyl (2Z,4S)-4-{[N-(3-methylbutanoyl)-L-phenylalanyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (3 entities in total)
• Functional Keywords: hand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Enterovirus A71
• Cellular location: Host cytoplasm : A9XG43
• Total number of polymer chains: 1
• Total formula weight: 21849.04

Authors

Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Li, N.,Cai, Y.,Li, J.,Lin, T. (deposition date: 2015-09-12, release date: 2016-03-30, Last modification date: 2023-11-08)

• Primary citation: Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T.; Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71; Biochim.Biophys.Acta, 1860:1299-1307, 2016; PubMed: 26987809; DOI: 10.1016/j.bbagen.2016.03.017

Experimental method

X-RAY DIFFRACTION (2.08 Å)