5DP6

Crystal Structure of EV71 3C Proteinase in complex with compound 7

Summary for 5DP6

Entry DOI	10.2210/pdb5dp6/pdb
Related	5DP3 5DP4 5DP5 5DP7 5DP8 5DP9 5DPA
Descriptor	3C proteinase, ethyl (2Z,4S)-4-{[N-(3-cyclopropylpropanoyl)-L-phenylalanyl]amino}-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate (2 entities in total)
Functional Keywords	hand, foot and mouth disease, 3c proteinase, peptidomimetics, drug design, rupintrivir, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Enterovirus A71
Cellular location	Host cytoplasm : A9XG43
Total number of polymer chains	4
Total formula weight	86505.07
Authors	Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Li, N.,Cai, Y.,Li, J.,Lin, T. (deposition date: 2015-09-12, release date: 2016-03-30, Last modification date: 2023-11-08)
Primary citation	Wu, C.,Zhang, L.,Li, P.,Cai, Q.,Peng, X.,Yin, K.,Chen, X.,Ren, H.,Zhong, S.,Weng, Y.,Guan, Y.,Chen, S.,Wu, J.,Li, J.,Lin, T. Fragment-wise design of inhibitors to 3C proteinase from enterovirus 71 Biochim.Biophys.Acta, 1860:1299-1307, 2016 Cited by PubMed: 26987809 DOI: 10.1016/j.bbagen.2016.03.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.01 Å)

Structure validation