5DP6

Crystal Structure of EV71 3C Proteinase in complex with compound 7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 5EB A 201

Chain	Residue
A	HIS40
A	GLY164
D	GLN22
A	LEU127
A	SER128
A	THR142
A	LYS143
A	GLY145
A	CYS147
A	HIS161
A	ILE162

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site_id	AC2
Number of Residues	15
Details	binding site for Di-peptide 5EB B 201 and CYS B 147

Chain	Residue
B	THR26
B	HIS40
B	LEU127
B	SER128
B	THR142
B	LYS143
B	GLY145
B	GLN146
B	GLY148
B	GLY149
B	HIS161
B	ILE162
B	GLY163
B	GLY164
C	GLN22

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site_id	AC3
Number of Residues	22
Details	binding site for Di-peptide HIS C 51 and SER D 111

Chain	Residue
C	LEU11
C	GLN17
C	TRP48
C	ILE49
C	GLU50
C	LYS52
C	ILE104
C	ASN105
C	MET109
C	PRO110
C	MET112
D	LEU11
D	GLN17
D	TRP48
D	ILE49
D	GLU50
D	LYS52
D	ILE104
D	ASN105
D	MET109
D	PRO110
D	MET112

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site_id	AC4
Number of Residues	22
Details	binding site for Di-peptide HIS C 51 and SER D 111

Chain	Residue
C	LEU11
C	GLN17
C	TRP48
C	ILE49
C	GLU50
C	LYS52
C	ILE104
C	ASN105
C	MET109
C	PRO110
C	MET112
D	LEU11
D	GLN17
D	TRP48
D	ILE49
D	GLU50
D	LYS52
D	ILE104
D	ASN105
D	MET109
D	PRO110
D	MET112

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site_id	AC5
Number of Residues	22
Details	binding site for Di-peptide HIS D 51 and SER C 111

Chain	Residue
C	LEU11
C	GLN17
C	TRP48
C	ILE49
C	GLU50
C	LYS52
C	ILE104
C	ASN105
C	MET109
C	PRO110
C	MET112
D	LEU11
D	GLN17
D	TRP48
D	ILE49
D	GLU50
D	LYS52
D	ILE104
D	ASN105
D	MET109
D	PRO110
D	MET112

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site_id	AC6
Number of Residues	22
Details	binding site for Di-peptide HIS D 51 and SER C 111

Chain	Residue
C	ASN105
C	MET109
C	PRO110
C	MET112
D	LEU11
D	GLN17
D	TRP48
D	ILE49
D	GLU50
D	LYS52
D	ILE104
D	ASN105
D	MET109
D	PRO110
D	MET112
C	LEU11
C	GLN17
C	TRP48
C	ILE49
C	GLU50
C	LYS52
C	ILE104

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