5DM2

Crystal structure of the plantazolicin methyltransferase BpumL in complex with triazolic desmethylPZN analog and SAH

5DM2 の概要

• エントリーDOI: 10.2210/pdb5dm2/pdb
• 関連するPDBエントリー: 5DLY 5DM1 5DM4
• 分子名称: Methyltransferase domain family, S-ADENOSYL-L-HOMOCYSTEINE, ethyl 2-(2-{2-[(1S)-4-carbamimidamido-1-(methylamino)butyl]-1,3-thiazol-4-yl}-5-methyl-1,3-oxazol-4-yl)-1,3-thiazole-4-carboxylate, ... (5 entities in total)
• 機能のキーワード: n-methyltransferase, plantazolicin, triazolic desmethylpzn analog, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bacillus pumilus ATCC 7061
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31325.66

構造登録者

Hao, Y.,Nair, S.K. (登録日: 2015-09-07, 公開日: 2015-09-23, 最終更新日: 2024-03-13)

• 主引用文献: Hao, Y.,Blair, P.M.,Sharma, A.,Mitchell, D.A.,Nair, S.K.; Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin.; Acs Chem.Biol., 10:1209-1216, 2015; PubMed: 25635336; DOI: 10.1021/cb501042a

実験手法

X-RAY DIFFRACTION (1.5 Å)