5DLW
Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)
Summary for 5DLW
| Entry DOI | 10.2210/pdb5dlw/pdb |
| Related | 5DLT 5DLV |
| Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
| Functional Keywords | autotaxin, enpp2, lpa, steroids, bile salts, tudca, hydrolase |
| Biological source | Rattus norvegicus (Norway Rat) |
| Total number of polymer chains | 1 |
| Total formula weight | 99341.95 |
| Authors | Keune, W.J.,Heidebrecht, T.,Joosten, R.P.,Perrakis, A. (deposition date: 2015-09-07, release date: 2016-04-13, Last modification date: 2020-07-29) |
| Primary citation | Keune, W.J.,Hausmann, J.,Bolier, R.,Tolenaars, D.,Kremer, A.,Heidebrecht, T.,Joosten, R.P.,Sunkara, M.,Morris, A.J.,Matas-Rico, E.,Moolenaar, W.H.,Oude Elferink, R.P.,Perrakis, A. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling. Nat Commun, 7:11248-11248, 2016 Cited by PubMed: 27075612DOI: 10.1038/ncomms11248 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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