5DLW

Crystal structure of Autotaxin (ENPP2) with tauroursodeoxycholic acid (TUDCA) and lysophosphatidic acid (LPA)

5DLW の概要

• エントリーDOI: 10.2210/pdb5dlw/pdb
• 関連するPDBエントリー: 5DLT 5DLV
• 分子名称: Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: autotaxin, enpp2, lpa, steroids, bile salts, tudca, hydrolase
• 由来する生物種: Rattus norvegicus (Norway Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 99341.95

構造登録者

Keune, W.J.,Heidebrecht, T.,Joosten, R.P.,Perrakis, A. (登録日: 2015-09-07, 公開日: 2016-04-13, 最終更新日: 2020-07-29)

• 主引用文献: Keune, W.J.,Hausmann, J.,Bolier, R.,Tolenaars, D.,Kremer, A.,Heidebrecht, T.,Joosten, R.P.,Sunkara, M.,Morris, A.J.,Matas-Rico, E.,Moolenaar, W.H.,Oude Elferink, R.P.,Perrakis, A.; Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling.; Nat Commun, 7:11248-11248, 2016; PubMed: 27075612; DOI: 10.1038/ncomms11248

実験手法

X-RAY DIFFRACTION (1.8 Å)