5DKC

Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe

5DKC の概要

• エントリーDOI: 10.2210/pdb5dkc/pdb
• 分子名称: Probable global transcription activator SNF2L2, ZINC ION, (2E)-1-(2-hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]hept-2-yl]prop-2-en-1-one, ... (4 entities in total)
• 機能のキーワード: swi-snf complex, chromatin remodeling, brg associated factors (baf), transcription, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P51531
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14767.32

構造登録者

Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S. (登録日: 2015-09-03, 公開日: 2015-10-14, 最終更新日: 2024-01-10)

• 主引用文献: Tallant, C.,Owen, D.R.,Gerstenberger, B.S.,Fedorov, O.,Savitsky, P.,Nunez-Alonso, G.,Fonseca, M.,Krojer, T.,Filippakopoulos, P.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Muller, S.,Knapp, S.; Crystal structure of the bromodomain of human BRM (SMARCA2) in complex with PFI-3 chemical probe; To Be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)