5DK5
Crystal structure of CRN-4-MES complex
Summary for 5DK5
Entry DOI | 10.2210/pdb5dk5/pdb |
Descriptor | Cell death-related nuclease 4, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total) |
Functional Keywords | deddh exonuclease, inhibitor, complex structure, dnase, rnase, hydrolase |
Biological source | Caenorhabditis elegans |
Total number of polymer chains | 2 |
Total formula weight | 72175.82 |
Authors | Hsiao, Y.-Y.,Yuan, H.S. (deposition date: 2015-09-03, release date: 2016-08-24, Last modification date: 2023-11-08) |
Primary citation | Huang, K.-W.,Hsu, K.-C.,Chu, L.-Y.,Yang, J.-M.,Yuan, H.S.,Hsiao, Y.-Y. Identification of Inhibitors for the DEDDh Family of Exonucleases and a Unique Inhibition Mechanism by Crystal Structure Analysis of CRN-4 Bound with 2-Morpholin-4-ylethanesulfonate (MES) J.Med.Chem., 59:8019-8029, 2016 Cited by PubMed: 27529560DOI: 10.1021/acs.jmedchem.6b00794 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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