5DK5
Crystal structure of CRN-4-MES complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| A | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0004536 | molecular_function | DNA nuclease activity |
| A | 0004540 | molecular_function | RNA nuclease activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006308 | biological_process | DNA catabolic process |
| A | 0006309 | biological_process | apoptotic DNA fragmentation |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006915 | biological_process | apoptotic process |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0060906 | biological_process | negative regulation of regulatory ncRNA-mediated heterochromatin formation |
| B | 0000175 | molecular_function | 3'-5'-RNA exonuclease activity |
| B | 0000467 | biological_process | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003697 | molecular_function | single-stranded DNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0004536 | molecular_function | DNA nuclease activity |
| B | 0004540 | molecular_function | RNA nuclease activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006308 | biological_process | DNA catabolic process |
| B | 0006309 | biological_process | apoptotic DNA fragmentation |
| B | 0006401 | biological_process | RNA catabolic process |
| B | 0006915 | biological_process | apoptotic process |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0060906 | biological_process | negative regulation of regulatory ncRNA-mediated heterochromatin formation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | CYS210 |
| A | CYS260 |
| A | CYS263 |
| A | CYS270 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue MES A 302 |
| Chain | Residue |
| A | ASP180 |
| A | ASP184 |
| A | HOH479 |
| A | GLU17 |
| A | PHE71 |
| A | THR72 |
| A | THR161 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 303 |
| Chain | Residue |
| A | ASP15 |
| A | GLU17 |
| A | ASP184 |
| A | HOH405 |
| A | HOH479 |
| A | HOH566 |
| A | HOH570 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue IPA A 304 |
| Chain | Residue |
| A | ALA159 |
| A | THR160 |
| A | THR161 |
| A | HOH659 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue IPA A 305 |
| Chain | Residue |
| A | TRP214 |
| A | HOH574 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue IPA A 306 |
| Chain | Residue |
| A | ARG215 |
| A | GLN276 |
| A | ASP280 |
| A | HOH431 |
| A | HOH679 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS210 |
| B | CYS260 |
| B | CYS263 |
| B | CYS270 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue MES B 302 |
| Chain | Residue |
| B | GLU17 |
| B | THR72 |
| B | THR161 |
| B | HIS179 |
| B | ASP180 |
| B | ASP184 |
| B | HOH410 |
| B | HOH426 |
| B | HOH431 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | ASP15 |
| B | GLU17 |
| B | ASP184 |
| B | HOH401 |
| B | HOH426 |
| B | HOH505 |
| B | HOH534 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue IPA B 304 |
| Chain | Residue |
| B | SER112 |
| B | ARG113 |
| B | ASN140 |
| B | TYR142 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue IPA B 305 |
| Chain | Residue |
| B | TYR27 |
| B | ARG118 |
| B | TYR122 |
| B | PHE236 |
| B | PHE291 |
| B | HOH473 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue IPA B 306 |
| Chain | Residue |
| B | ARG215 |
| B | ARG216 |
| B | ASP280 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue IPA B 307 |
| Chain | Residue |
| B | ASP111 |
| B | ASN162 |
| B | HOH431 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 360 |
| Details | Domain: {"description":"Exonuclease","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27529560","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DK5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18981218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27529560","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CM5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5DK5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
