5DJM

Structure of WT Human Glutathione Transferase in complex with cisplatin in the absence of glutathione.

Summary for 5DJM

• Entry DOI: 10.2210/pdb5djm/pdb
• Related: 5DCG 5DJL
• Descriptor: Glutathione S-transferase P, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PLATINUM (II) ION, ... (4 entities in total)
• Functional Keywords: anticancer cisplatin, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 47731.25

Authors

Parker, L.J. (deposition date: 2015-09-02, release date: 2016-11-02, Last modification date: 2023-09-27)

• Primary citation: Parker, L.J.,Italiano, L.C.,Hancock, N.C.,Aitken, J.,Harris, H.H.,Hansen, G.,Ascher, D.B.,Morton, C.J.,Parker, M.W.,Lo Bello, M.; A structure-based mechanism of cisplatin resistance mediated by Glutathione Transferase P1-1; Proc.Natl.Acad.Sci.USA, 2019

Experimental method

X-RAY DIFFRACTION (1.9 Å)