5DI1

MAP4K4 in complex with an inhibitor

Summary for 5DI1

• Entry DOI: 10.2210/pdb5di1/pdb
• Related: 4ZP5
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 4, 4-{6-amino-5-[4-(methylsulfonyl)phenyl]pyridin-3-yl}phenol (3 entities in total)
• Functional Keywords: kinase, inhibitor, complex, medicinal chemistry, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : O95819
• Total number of polymer chains: 2
• Total formula weight: 71237.80

Authors

Liu, S. (deposition date: 2015-08-31, release date: 2016-01-13, Last modification date: 2023-09-27)

• Primary citation: Ammirati, M.,Bagley, S.W.,Bhattacharya, S.K.,Buckbinder, L.,Carlo, A.A.,Conrad, R.,Cortes, C.,Dow, R.L.,Dowling, M.S.,El-Kattan, A.,Ford, K.,Guimaraes, C.R.,Hepworth, D.,Jiao, W.,LaPerle, J.,Liu, S.,Londregan, A.,Loria, P.M.,Mathiowetz, A.M.,Munchhof, M.,Orr, S.T.,Petersen, D.N.,Price, D.A.,Skoura, A.,Smith, A.C.,Wang, J.; Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.; Acs Med.Chem.Lett., 6:1128-1133, 2015; PubMed: 26617966; DOI: 10.1021/acsmedchemlett.5b00215

Experimental method

X-RAY DIFFRACTION (2.9 Å)