5DFC

Crystal structure of BRD2(BD2) W370F mutant with ligand I-BET 762 bound

Summary for 5DFC

Entry DOI	10.2210/pdb5dfc/pdb
Descriptor	Bromodomain-containing protein 2, GLYCEROL, NONAETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	transcription factors, bet bromodomains, protein mutation engineering, molecular probes, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P25440
Total number of polymer chains	1
Total formula weight	14325.54
Authors	Tallant, C.,Baud, M.,Lin-Shiao, E.,Chirgadze, D.Y.,Ciulli, A. (deposition date: 2015-08-26, release date: 2015-11-11, Last modification date: 2024-01-10)
Primary citation	Baud, M.G.,Lin-Shiao, E.,Zengerle, M.,Tallant, C.,Ciulli, A. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. J.Med.Chem., 59:1492-1500, 2016 Cited by PubMed: 26367539 DOI: 10.1021/acs.jmedchem.5b01135 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation