5DEX

Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, phenyl-ACEPC

Summary for 5DEX

Entry DOI	10.2210/pdb5dex/pdb
Related	5DDN 5DDX 5DE4
Descriptor	Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A, GLYCINE, ... (5 entities in total)
Functional Keywords	transport protein, receptor
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	65475.66
Authors	Mou, T.-C.,Conti, P.,Pinto, A.,Tamborini, L.,Sprang, S.R.,Hansen, K.B. (deposition date: 2015-08-26, release date: 2016-09-14, Last modification date: 2023-09-27)
Primary citation	Lind, G.E.,Mou, T.C.,Tamborini, L.,Pomper, M.G.,De Micheli, C.,Conti, P.,Pinto, A.,Hansen, K.B. Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits. Proc. Natl. Acad. Sci. U.S.A., 2017 Cited by PubMed: 28760974 DOI: 10.1073/pnas.1707752114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation