5DEU

Crystal structure of TET2-5hmC complex

Summary for 5DEU

• Entry DOI: 10.2210/pdb5deu/pdb
• Related: 5D9Y
• Descriptor: Methylcytosine dioxygenase TET2, chimeric construct, DNA (5'-D(*AP*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), DNA (5'-D(P*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), ... (9 entities in total)
• Functional Keywords: 5-methylcytosine dioxygenase, tet2, 5hmc, protein-dna complex, oxidoreductase-dna complex, oxidoreductase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 59100.83

Authors

Hu, L.,Cheng, J.,Rao, Q.,Li, Z.,Li, J.,Xu, Y. (deposition date: 2015-08-26, release date: 2015-11-04, Last modification date: 2023-09-27)

• Primary citation: Hu, L.,Lu, J.,Cheng, J.,Rao, Q.,Li, Z.,Hou, H.,Lou, Z.,Zhang, L.,Li, W.,Gong, W.,Liu, M.,Sun, C.,Yin, X.,Li, J.,Tan, X.,Wang, P.,Wang, Y.,Fang, D.,Cui, Q.,Yang, P.,He, C.,Jiang, H.,Luo, C.,Xu, Y.; Structural insight into substrate preference for TET-mediated oxidation.; Nature, 527:118-122, 2015; PubMed: 26524525; DOI: 10.1038/nature15713

Experimental method

X-RAY DIFFRACTION (1.801 Å)