5DE2
Structural mechanism of Nek7 activation by Nek9-induced dimerisation
Summary for 5DE2
| Entry DOI | 10.2210/pdb5de2/pdb |
| Related | 2WQM 2WQN |
| Descriptor | Serine/threonine-protein kinase Nek7, Serine/threonine-protein kinase Nek9 (3 entities in total) |
| Functional Keywords | protein kinase, mitosis, protein-protein interaction, transferase |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Nucleus: Q8TDX7 Cytoplasm : Q8K1R7 |
| Total number of polymer chains | 4 |
| Total formula weight | 75771.28 |
| Authors | Haq, T.,Bayliss, R. (deposition date: 2015-08-25, release date: 2015-11-11, Last modification date: 2024-01-10) |
| Primary citation | Haq, T.,Richards, M.W.,Burgess, S.G.,Gallego, P.,Yeoh, S.,O'Regan, L.,Reverter, D.,Roig, J.,Fry, A.M.,Bayliss, R. Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization. Nat Commun, 6:8771-8771, 2015 Cited by PubMed: 26522158DOI: 10.1038/ncomms9771 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.78 Å) |
Structure validation
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