5DE2

Structural mechanism of Nek7 activation by Nek9-induced dimerisation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000922	cellular_component	spindle pole
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005815	cellular_component	microtubule organizing center
A	0005874	cellular_component	microtubule
A	0006468	biological_process	protein phosphorylation
A	0007346	biological_process	regulation of mitotic cell cycle
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032206	biological_process	positive regulation of telomere maintenance
A	0033044	biological_process	regulation of chromosome organization
A	0035865	biological_process	cellular response to potassium ion
A	0046872	molecular_function	metal ion binding
A	0051225	biological_process	spindle assembly
A	0106310	molecular_function	protein serine kinase activity
A	0140677	molecular_function	molecular function activator activity
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	0000166	molecular_function	nucleotide binding
B	0000922	cellular_component	spindle pole
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005815	cellular_component	microtubule organizing center
B	0005874	cellular_component	microtubule
B	0006468	biological_process	protein phosphorylation
B	0007346	biological_process	regulation of mitotic cell cycle
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0032206	biological_process	positive regulation of telomere maintenance
B	0033044	biological_process	regulation of chromosome organization
B	0035865	biological_process	cellular response to potassium ion
B	0046872	molecular_function	metal ion binding
B	0051225	biological_process	spindle assembly
B	0106310	molecular_function	protein serine kinase activity
B	0140677	molecular_function	molecular function activator activity
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGQFSEVYrAaclldgvp..........VALK

Chain	Residue	Details
A	ILE40-LYS63

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VmHrDIKpaNVFI

Chain	Residue	Details
A	VAL157-ILE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	26
Details	Region: {"description":"NTE motif","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2WQN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Autoinhibitory","evidences":[{"source":"PubMed","id":"19941817","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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