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5DE2

Structural mechanism of Nek7 activation by Nek9-induced dimerisation

Functional Information from GO Data
ChainGOidnamespacecontents
A0000922cellular_componentspindle pole
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005813cellular_componentcentrosome
A0005815cellular_componentmicrotubule organizing center
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0006468biological_processprotein phosphorylation
A0007346biological_processregulation of mitotic cell cycle
A0032212biological_processpositive regulation of telomere maintenance via telomerase
A0035865biological_processcellular response to potassium ion
A0046872molecular_functionmetal ion binding
A0051225biological_processspindle assembly
A0051973biological_processpositive regulation of telomerase activity
A0106310molecular_functionprotein serine kinase activity
A0140677molecular_functionmolecular function activator activity
A1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
A1904355biological_processpositive regulation of telomere capping
B0000922cellular_componentspindle pole
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005813cellular_componentcentrosome
B0005815cellular_componentmicrotubule organizing center
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0006468biological_processprotein phosphorylation
B0007346biological_processregulation of mitotic cell cycle
B0032212biological_processpositive regulation of telomere maintenance via telomerase
B0035865biological_processcellular response to potassium ion
B0046872molecular_functionmetal ion binding
B0051225biological_processspindle assembly
B0051973biological_processpositive regulation of telomerase activity
B0106310molecular_functionprotein serine kinase activity
B0140677molecular_functionmolecular function activator activity
B1900227biological_processpositive regulation of NLRP3 inflammasome complex assembly
B1904355biological_processpositive regulation of telomere capping
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGQFSEVYrAaclldgvp..........VALK
ChainResidueDetails
AILE40-LYS63

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VmHrDIKpaNVFI
ChainResidueDetails
AVAL157-ILE169

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP161
BASP161

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000305|PubMed:19941817, ECO:0007744|PDB:2WQN
ChainResidueDetails
BILE40
BLYS63
AILE40
ALYS63

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Autoinhibitory => ECO:0000269|PubMed:19941817
ChainResidueDetails
APHE97
BPHE97

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER5
BSER5

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by NEK9 => ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:26522158
ChainResidueDetails
ASER195
BSER195

221051

PDB entries from 2024-06-12

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