5DC3

Complex of yeast 80S ribosome with non-modified eIF5A

これはPDB形式変換不可エントリーです。

5DC3 の概要

• エントリーDOI: 10.2210/pdb5dc3/pdb
• 分子名称: 18S ribosomal RNA, 40S ribosomal protein S8-A, 40S ribosomal protein S9-A, ... (86 entities in total)
• 機能のキーワード: ribosome, complex, eif5a
• 由来する生物種: Saccharomyces cerevisiae S288c; 詳細
• タンパク質・核酸の鎖数: 163
• 化学式量合計: 6288663.58

構造登録者

Melnikov, S.,Mailliot, J.,Shin, B.-S.,Rigger, L.,Yusupova, G.,Micura, R.,Dever, T.E.,Yusupov, M. (登録日: 2015-08-23, 公開日: 2016-06-01, 最終更新日: 2024-01-10)

主引用文献

Melnikov, S.,Mailliot, J.,Shin, B.S.,Rigger, L.,Yusupova, G.,Micura, R.,Dever, T.E.,Yusupov, M.
Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome.
J.Mol.Biol., 428:3570-3576, 2016

PubMed Abstract: Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-Å resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A-ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A-ribosome association.

PubMed: 27196944
DOI: 10.1016/j.jmb.2016.05.011

実験手法

X-RAY DIFFRACTION (3.25 Å)