5D9K
Rsk2 N-terminal Kinase in Complex with BI-D1870
Summary for 5D9K
Entry DOI | 10.2210/pdb5d9k/pdb |
Related | 5D9L |
Descriptor | Ribosomal protein S6 kinase alpha-3, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one, GLYCEROL, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51812 |
Total number of polymer chains | 2 |
Total formula weight | 76928.72 |
Authors | Appleton, B.A. (deposition date: 2015-08-18, release date: 2015-09-02, Last modification date: 2024-03-06) |
Primary citation | Jain, R.,Mathur, M.,Lan, J.,Costales, A.,Atallah, G.,Ramurthy, S.,Subramanian, S.,Setti, L.,Feucht, P.,Warne, B.,Doyle, L.,Basham, S.,Jefferson, A.B.,Lindvall, M.,Appleton, B.A.,Shafer, C.M. Discovery of Potent and Selective RSK Inhibitors as Biological Probes. J.Med.Chem., 58:6766-6783, 2015 Cited by PubMed: 26270416DOI: 10.1021/acs.jmedchem.5b00450 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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