5D8U

2009 H1N1 PA endonuclease mutant E119D in complex with L-742,001

Summary for 5D8U

Entry DOI	10.2210/pdb5d8u/pdb
Related	5CCY 5CGV 5CL0 5CZN 5D2O 5D42 5D4G 5D9J
Descriptor	Polymerase acidic protein, MANGANESE (II) ION, (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, ... (4 entities in total)
Functional Keywords	influenza, resistance, endonuclease inhibitor, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Influenza A virus More
Total number of polymer chains	1
Total formula weight	23658.09
Authors	Kumar, G.,White, S.W. (deposition date: 2015-08-18, release date: 2016-03-16, Last modification date: 2023-09-27)
Primary citation	Song, M.S.,Kumar, G.,Shadrick, W.R.,Zhou, W.,Jeevan, T.,Li, Z.,Slavish, P.J.,Fabrizio, T.P.,Yoon, S.W.,Webb, T.R.,Webby, R.J.,White, S.W. Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113:3669-3674, 2016 Cited by PubMed: 26976575 DOI: 10.1073/pnas.1519772113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation