5D7Y
Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18
5D7Y の概要
エントリーDOI | 10.2210/pdb5d7y/pdb |
分子名称 | Capsid protein, methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-{[4-(3-hydroxypenta-1,4-diyn-3-yl)piperidin-1-yl]methyl}-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate (2 entities in total) |
機能のキーワード | capsid, core protein, hepadnavirus, icosahedral, assembly effector, assembly accelerator, allosteric modulator, hap, virus-inhibitor complex, virus/inhibitor |
由来する生物種 | Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 68334.64 |
構造登録者 | |
主引用文献 | Venkatakrishnan, B.,Katen, S.P.,Francis, S.,Chirapu, S.,Finn, M.G.,Zlotnick, A. Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. J.Virol., 90:3994-4004, 2016 Cited by PubMed: 26842475DOI: 10.1128/JVI.03058-15 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.894 Å) |
構造検証レポート
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