5D7P

Crystal structure of human Sirt2 in complex with ADPR and EX-243

5D7P の概要

• エントリーDOI: 10.2210/pdb5d7p/pdb
• 分子名称: NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: hydrolase, human sirtuin 2, inhibitor complex, deacylase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71183.86

構造登録者

Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M. (登録日: 2015-08-14, 公開日: 2015-12-02, 最終更新日: 2024-01-10)

• 主引用文献: Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M.; Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking.; Acta Crystallogr.,Sect.F, 71:1498-1510, 2015; PubMed: 26625292; DOI: 10.1107/S2053230X15019986

実験手法

X-RAY DIFFRACTION (1.76 Å)