5D70

Crystal structure of MOR03929, a neutralizing anti-human GM-CSF antibody Fab fragment in complex with human GM-CSF

5D70 の概要

• エントリーDOI: 10.2210/pdb5d70/pdb
• 分子名称: Granulocyte-macrophage colony-stimulating factor, Immunglobulin G1 Fab fragment, heavy chain, Immunglobulin G1 Fab fragment, light chain, ... (5 entities in total)
• 機能のキーワード: gm-csf, affinity maturation, phage display, cytokine, antibody, proteros biostructures gmbh, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P04141
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 62139.22

構造登録者

Eylenstein, R.,Weinfurtner, D.,Steidl, S.,Boettcher, J.,Augustin, M. (登録日: 2015-08-13, 公開日: 2015-10-14, 最終更新日: 2024-01-10)

• 主引用文献: Eylenstein, R.,Weinfurtner, D.,Hartle, S.,Strohner, R.,Bottcher, J.,Augustin, M.,Ostendorp, R.,Steidl, S.; Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody.; Mabs, 8:176-186, 2016; PubMed: 26406987; DOI: 10.1080/19420862.2015.1099774

実験手法

X-RAY DIFFRACTION (2.06 Å)