5D3I

Crystal structure of the SSL3-TLR2 complex

Summary for 5D3I

• Entry DOI: 10.2210/pdb5d3i/pdb
• Related: 5D3D
• Descriptor: Toll-like receptor 2, Staphylococcal Superantigen-Like protein 3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: superantigens, superantigen-like proteins, ssl, ssl3, toll-like receptor 2, tlr2, tlr6, immunology, inflammation, inhibition, lipopeptide, phosphatidylcholine, pc, immune evasion, innate immunity, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 88156.46

Authors

Feitsma, L.J.,Huizinga, E.G. (deposition date: 2015-08-06, release date: 2015-08-19, Last modification date: 2020-07-29)

• Primary citation: Koymans, K.J.,Feitsma, L.J.,Brondijk, T.H.,Aerts, P.C.,Lukkien, E.,Lossl, P.,van Kessel, K.P.,de Haas, C.J.,van Strijp, J.A.,Huizinga, E.G.; Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).; Proc.Natl.Acad.Sci.USA, 112:11018-11023, 2015; PubMed: 26283364; DOI: 10.1073/pnas.1502026112

Experimental method

X-RAY DIFFRACTION (3.2 Å)