5D29

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU241

5D29 の概要

• エントリーDOI: 10.2210/pdb5d29/pdb
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: prostate-specific membrane antigen, naaladase, phosphoramidate, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 81370.32

構造登録者

Barinka, C.,Novakova, Z.,Pavlicek, J. (登録日: 2015-08-05, 公開日: 2016-04-27, 最終更新日: 2020-07-29)

• 主引用文献: Novakova, Z.,Wozniak, K.,Jancarik, A.,Rais, R.,Wu, Y.,Pavlicek, J.,Ferraris, D.,Havlinova, B.,Ptacek, J.,Vavra, J.,Hin, N.,Rojas, C.,Majer, P.,Slusher, B.S.,Tsukamoto, T.,Barinka, C.; Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity.; J.Med.Chem., 59:4539-4550, 2016; PubMed: 27074627; DOI: 10.1021/acs.jmedchem.5b01806

実験手法

X-RAY DIFFRACTION (1.8 Å)