5D29
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU241
5D29 の概要
エントリーDOI | 10.2210/pdb5d29/pdb |
分子名称 | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
機能のキーワード | prostate-specific membrane antigen, naaladase, phosphoramidate, hydrolase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 81370.32 |
構造登録者 | |
主引用文献 | Novakova, Z.,Wozniak, K.,Jancarik, A.,Rais, R.,Wu, Y.,Pavlicek, J.,Ferraris, D.,Havlinova, B.,Ptacek, J.,Vavra, J.,Hin, N.,Rojas, C.,Majer, P.,Slusher, B.S.,Tsukamoto, T.,Barinka, C. Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J.Med.Chem., 59:4539-4550, 2016 Cited by PubMed: 27074627DOI: 10.1021/acs.jmedchem.5b01806 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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