5CZH
EGFR L858R MUTANT IN COMPLEX WITH AN OPTIMAL PEPTIDE SUBSTRATE
Summary for 5CZH
Entry DOI | 10.2210/pdb5czh/pdb |
Related | 5CZI |
Descriptor | Epidermal growth factor receptor, Peptide substrate (3 entities in total) |
Functional Keywords | egfr, l858r, kinase, egf, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 2 |
Total formula weight | 38928.61 |
Authors | |
Primary citation | Begley, M.J.,Yun, C.H.,Gewinner, C.A.,Asara, J.M.,Johnson, J.L.,Coyle, A.J.,Eck, M.J.,Apostolou, I.,Cantley, L.C. EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat.Struct.Mol.Biol., 22:983-990, 2015 Cited by PubMed: 26551075DOI: 10.1038/nsmb.3117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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